Seroquel may work better than lithium for some people. Depends on the individual and in my experience they both work very differently and FEEL very different. Personally lithium worked well but I preferred seroquel (even though I took both together). I liked how seroquel calmed me down and helped me sleep and helped with depression. But lithium was good because it didn't have the weight gain or the cognitive effects. Just personal preference and how effective each med is to the individual.