I smoked pot with my effexor all the time. My dr and pdoc would tell me it made the effexor not work as well but i didnt have any side effects other than possibly that. I have quit since the 3rd now and dont see any real differences in my depression so in my mind it didnt matter. I still jump up and down all the time. Tho i do find myself a tad more agressive without the pot, which for me means i tend to say more ugly things to people or less considerate or something.