Seroquel is one of the only drugs that has worked for me. I was on doses up to 1500 mg (nearly double the recommended max). I was on 800-1200 mg for the longest time.

I was really afraid of it because I worked in a psych facility where the psychiatrist used it to snow a lot of the patients. I was terrified that I would be snowed too. My pdoc had me go up very slowly over probably 2-3 months (to maybe 300 mg) and while it helped me sleep I wasn't overly sedated. I was on it with a really high dose of depakote too and still wasn't too sedated. When XR came out I switched to that and it made life a lot better; all the sedation during the day left but I still slept at night.

I was on it for 9 years before it stopped working and I changed to clozaril. I did gain weight on it but also lost about 60 lbs at one point on it.

I found it a good med but not perfect. I'm still waiting for the perfect med .