I've been taking seroquel 50mg 1-2 times at bedtime going on 2 weeks now, but only as needed. I was prescribed this along with lamictal and so far I haven't had any crazy side effects. I don't take the seroquel if I'm falling to sleep on my own, I take one if I'm not sleepy, and take 2 if I'm being kept up because of my thoughts. I also found that taking two helps me when I feel a mixed episode coming on, in which I only have at night now. Good luck!