I'm sorry you are having such a difficult time.
It sounds like maybe the reduced Seroquel dosage may be responsible (at least partially so) for the letdown in mood.
I am sorry about the skin infection. I am sure you would have not risked possibly infecting anyone else if you'd known it was contagious.
Things like this also get me down. I'm tired of physical problems. It wears on my self-esteem, too, even temporary things.
It seems like you've been through a lot lately.
Maybe an earlier appt with the pdoc would feel helpful?
Please take good care of yourself and stay safe.

WC