Hi WC, I was on Latuda for about 18 months. Initially, it helped my depression quite a bit. Then when summer came, I didn't need the Latuda so much. But the worst problem was that I developed a severe tremor from it...jaw, hands, feet. Not only was I self-conscious because of the tremor, but my pdoc was concerned about tardive dynkenesia. So I decided to go off the Latuda. I dropped the dose from 120mg down to nothing over about 5 weeks. I have not experienced any withdrawal symptoms. The tremor took a couple of months to go away, but it finally has.