All of the 2nd generation AP's can adversely affect blood glucose level unfortunately. It's one of the many bad side effects they have in common, like weight gain--which of course is not unrelated. Some are worse than others.I haven't needed anything stronger than Seroquel or Abilify so I don't know if Latuda would be effective for you, but the only bad side effect I had was akathisia; bad enough, but easily treated with a good dose of propranolol. My PCP thinks it's the reason my glucose is a little higher than it should be, but I really don't eat very healthily either and I blame that.