I know I'm more likely to respond to someone I have something in common with, which you would mention in your first message. Not all, but at least one interest. It's at least a conversation starter. Also, if I stated in my ad that I have a certain desired location or other particulars, I ignore those who can't read my preferences. If it is a bonafide dating site, you should connect with someone sooner or later. Just don't expect too much too soon. It might take a while so just be patient and be yourself.
Different women want different things, but a lot of us who have been online a long time have seen it all and have learned to be very choosy.
Good luck in your endeavor!