My experience with Siroquil was 20 minutes after taking only 150mg at hs, I was out like a light. I didn't find it really helped with the mind chatter, but I have since been taken off it, as my PDoc switched out the epival, siroquil, and celexa for Saphris and Lamotrigine. I have noticed that since going off the siroquil I have been cycling like crazy and a wave of emotions I don't know what to do with.

Best of luck with the med change

Hope your changes work.