My pdoc increases and decreases my Seroquel, depending on whether I am getting manic/mixed or not. I was on 600 mg for a while, and it worked for an acute onset of a manic episode most recently. It was the one thing that pulled me out of it, with time.

The thing is, I became very depressed after and wondered why I was crying every day and hardly making it. This was while on a high dose of Seroquel.
The weird thing is, we played around with my meds, and a few weeks after lowering my Seroquel to 400 mg, the severe depression went away. At first, I became the bad kind of irritable, angry hypomanic when lowering it, but things leveled out afterwards. I feel much better than before, although I will always deal with some symptoms. I have my really bad days, but things could be a lot worse.

This makes me wonder: was the higher dose of Seroquel actually making me more depressed, since my depression improved after adjusting to a lower dose?
I think about this, since I was a lot more depressed on 600-800mg range. Or, I wonder, if the swing from mixed/mania to severe depression was unrelated to being on a high Seroquel dose?

I know nobody can really answer, but it makes me wonder, whether high dose Seroquel was causing the depression, although it helped with mania. I am also wondering if anyone has experienced a higher dose of Seroquel or any medication actually making the BP worse, but then things got better for you on a lower dose?