I'm really sensitive to drugs even at low doses. My doc put me on Seroquel 3 weeks ago starting at 25 mg and working my way to 100mg at bed time. Once I was on the 100mg about a week into it my mood started to go downhill and to the point of having really bad thoughts this past week. Freaked me out so I've started tapering off and am at 50mg at bed time last 2 nights and feel better again ( though doubt such a low dose will do anything much for evening my mood in the long run). I'm just going to wean off in next few days and take it up with my doc when I see him in August. That's just my experience, take it with a grain of salt. Good luck