I lost weight on lexapro and the second time i was on wellbutrin xl. i only lost weight because i couldn't eat. I would try but could only eat a few bites of food everyday. Most people that can't eat end up holding onto weight or gaining. Not to many people lose weight while being on an anti depressant. yes i have tryed cymbalta. It was like a placebo. it didn't touch me. The best way to lose weight is to cut down what you eat, no eating before bed and exercise.