I have been put on this combo, pretty much as a last resort. It stopped acute mania. The dr at IP say it would also work against the depressive phase, and esp. Depakote.

In the past Depakote caused significant weight gain. Now Seroquel is also a moderate weight-gainer, so I am very concerned.

What have your experiences been for those also on this combo?

My dosages are being worked out - probably 550 mg of Seroquel + 1000 mg of Depakote.

Thanks!