I have never been on Depakote but have been on seroquel, and currently take 25mg of it before bed to help me sleep. From what I know, seroquel increases appetite and the desire for more unhealthy foods which can in turn cause weight gain. (If I am inaccurate on this someone can feel free to jump in!) I have been on seroquel on and off throughout the years and have never noticed any weight gain. If you keep your eating habits in check and exercise regularly, you shouldn't have a problem. If you do notice some weight gain, perhaps exercising more often/more intensely and re-evaluating your eating plan would help. Good luck!