I take 1000mg depakote and 300mg seroquel. They are very effective for me, and I have had no luck switching to something else. Seroquel makes me crave sweets a lot and depakote makes you retain water and gain weight, too. despite it, I choose to be sane. But, if it is at all possible to try something less likely to cause so much weight gain, like latuda or abilify or geodon, I would ask your doctor about those first.