I've been in a severe depression on and off for many years. My pdoc changed my med combo because my daughter was going off to college and no one, including myself, thought it would go well. To my surprise, this combo has stabilized me and there is no sign of the severe depression or anxiety I had before. I hope it continues to improve. I had given up as well. Your answer may be just around the corner out of sight. Hang in there. Sending big hugs.