Depakote certainly didn't work for my depression. My doc tried to go with it as monotherapy, and I spent three weeks in the worst depression of my life. My doc said it can work to treat both mania and depression in the short term, but it's long-term control of depression is not good.
He added Latuda and Lamictal, and those pulled me out of the depression.
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Meds: Latuda, Lamictal XR, Vyvanse, Seroquel, Klonopin
Supplements: Monster Energy replacement.  Also DLPA, tyrosine, glutamine, and tryptophan
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