The answer will be different for each person but here is what I'd suggest in your situation. Is your situation at work likely temporary or is it realistic to believe it will get better given time and getting some help? It's best to be employed if at all possible. Disability doesn't pay much and is pretty stressful. If switching jobs you will need to learn the job and be around new people and not have the perks seniority provides or FMLA options. At your current job you likely have somewhat of a routine and can probably get by on auto pilot at least sometimes. Starting new jobs is often very stressful so it's important to consider the pros and cons of course. If the situation at work is not likely to improve and you're at the end of your rope on what you can handle, changing jobs is a smart decision. If you are REALLY at the end of your rope and would not be able to endure the stress of a new job, disability might be the only choice. Good luck no matter what you decide.