I take 800mg of Seroquel XR and I'm not zombified and I don't feel flat or over medicated. It worked to take me out of a mixed episode last month and the only complaint I have is that it makes me oversleep in the morning. Otherwise, it works for me. I started on 600mg and had to go up as 600mg was not controlling the agitation I had with the mixed mania. I've had good results but I understand everyone is different when it comes to medication.