I never tried this but allegedly if you can keep depakote below 1000 mg it isn't so bad for weight gain. Whether you can do this or not is the problem.

I lost a lot of weight on depakote combined with seroquel and some other weight gainer using a low gylcemic index diet. My plan is to start the same diet Sept 1 and hope it works with clozapine. It worked really well the last time......

Sorry that you are going through that. I lost about 60-70 lbs one year and kept it off for about 18 months and then med changes caused me to regain a little and then clozapine a lot and now I have to lose more than ever before.

Have you ever tried metformin? It helped me lose a few lbs. and better yet stopped me from gaining any more (until a big dose increase) and my doctor has been really conservative with the dose; I think I'd lose more on a higher dose but he's worried it would lower my blood sugar too much.