I tried saphris samples given by my Pdoc. The taste is beyond nasty. It gave me terrible akathesia (similar to restless leg, but your whole body) it was different than the quetiapine (seroquel) that I was on but I can't say it was better. The final decision was financial for me. QUetiapine is an old med and covered by my insurance so it was $50. The saphris was going to cost $1,000 per month so Q it is for me.