This is an easy one for me. I would give up the depression for sure. It seems we all are on a bit of a continuum with regards to how depressive and manic episodes represent themselves. For me, the depression hits hard and everything becomes difficult (thinking, concentration, accomplishing simple tasks, sleeping too much, no interest in anything). When I am manic, I really think it is more of a hypomania. Once I quit drinking (almost a year now), my hypomanic episodes are pretty easy for me to sail through. I can concentrate and I just simply "get s@#$ done".