I took loxapine for a while. It seemed like it was going to work but before we could get the dose high enough for it to really work I developed EPS and had to go off it. It has a neat little trick that it breaks down into amoxapine which is a tricyclic AD so it is good for depression. I think EPS is fairly rare on it; for some reason I get EPS easily which pretty much rules out other older drugs. Until the EPS it was pretty side effect free.