I've been on Zoloft for about 16 years. Every time I try to stop--even when I taper very slowly--my depression and anxiety return. The last time I tried to stop, my decision was based on a concern that SSRIs can make depression worse over the long term. But I'm starting to think the risks of coming off are greater than the risks of staying on. Anyone else reconciled to being on SSRIs for life? Anyone else been on SSRIs for decades?