So seroquel has a very short half-life and indeed there is an XR version. I understand it's usually prescribed at bedtime due to the drowsiness, but it makes me wonder about how fast it might lose effectiveness over the following day due to that short half life. Especially when it's often dosed once a day.

Does anybody know of any semi "official" writing/opinions on this topic? Obviously a medication's therapeutic lifespan and half-life are not always one and the same. It would seem to me that a bedtime dose of seroquel should be working noticeably less well by evening of the following day, but in my case I'm taking it as a mood stabilizer rather than (for example) an antipsychotic, so I imagine it's harder for somebody like me to tell.

I've been searching around for info on this but so far all I've come up with is unbacked speculation on forums