I am a lightweight with psychoactive drugs and the pdoc says there is an interaction with straterra that makes both more effective. She reduced my straterra from 80mg to 60mg when I started the wellbutrin titration. I see from your signature you take twice as much lamictal as I do. I take 2.5mg of saphris and sleep like a log; that's only a quarter of the minimum therapeutic dose. We all react differently.