I do 450mg of the XL. We'd tried the SR at a lower dose, but it wasn't doing enough.

At first 450 made me a little happyhypo (which was great after a year of brutal depression), but I settled down soon enough.

One thing I might have worried about more was Wellbutrin's power to lower your seizure threshold as its dose gets higher, but I already was taking a sizable dose of lamotrigine. Haven't had any issues.