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Sep 25, 2017 at 05:00 PM
Ketamine might work...
Quote:
Depression[edit]
See also: Esketamine §*Depression, and List of investigational antidepressants
Ketamine has been tested as a rapid-acting antidepressant[45] for treatment-resistant depression in bipolar disorder, and major depressive disorder.[46] Ketamine's antidepressant effect has a short duration of action.[47] The quality of the evidence supporting its use as an antidepressant is generally low.[47][48] Currently, ketamine is not approved for the treatment of depression, and so this is an off-label use. As of June 2017, esketamine, the S(+) enantiomer of ketamine, is in phase III clinical trials for intranasal treatment of depression.[49][50]
Ketamine is given by a single intravenous infusion at doses less than those used in anesthesia, and preliminary data indicate it produces a rapid (within 2*hours) and relatively sustained (about 1–2 weeks long) reduction in symptoms in some people.[51] Initial studies have resulted in interest due to its rapid onset,[52] and because it appears to work by blocking NMDA receptors for glutamate, a different mechanism from most modern antidepressants that operate on other targets.[53]
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