Hi folks, my pdoc and I have started on a very systematic med search and I've been doing a lot of research into the scientific literature and the state of knowledge. (Feel free to PM me questions, BTW, I've spent thousands of hours over decades on understanding pharma.)

FWIW I have ultrarapid cycling bipolar II so I'm asking my questions from the standpoint of having an unstable mood on a period of hours to days, on a background of years-long moderate to severe depressive episodes.

Has anybody else found that seroquel improves their baseline mood (if you default to depressed like I do) and/or improves their ability to bounce back to that baseline when life throws a curveball and makes you crash?

I'm pretty sure that's what I'm seeing at this point.

However, it would appear that seroquel really does not act as a stabilizer for me to the same extent Zyprexa did. So, overall an improvement, but I'm still quite unstable.

I'm curious if anyone else has had this experience. So far I think I may continue with the seroquel at least another month before doing anything else, and if it does prove out, probably try to stay on it and figure out something else for the instability.