Sorry you're not doing well. Is there anything we can do to help?

I know you feel hopeless, but for what it's worth, Seroquel *did* help with my depression when the dose got high enough. (I had to go off it for health reasons, but not everyone gets the same reactions.) So hopefully Seroquel does the trick for you. Just thought I'd share my experience so that you don't feel so hopeless. It took me about 10 days from the dose increase to feel better.