I notice all the meds you have been on. Has any doctor tried combinations of these meds? I was depressed and pretty Treatment resistant The partial solution was to have med combination that work on three neurotransmitters:Serotonin, Norepinephrine, and Dopamine. I know everyone responds differently so I won't name the meds I am on. I say this is only a partial solution because I've occasionally have had breakthrough depression. As a matter fact I'm coming out of my 4th episode (in 27 years) of MDD that started in late July. I think the combo I am on makes for fewer, less disabling and shorter episodes of Major Depressive Disorder when there is a breakthrough.