Hi everybody. I've suffered from depression and anxiety for as long as I can remember. However, I don't want to regurgitate all that "stuff" now. I'd just like to add a few points of interest that may also become questions. Firstly, it took many ads before pdoc tried me on Prozac, which worked wonders. Over the years I've sometimes changed to Zoloft (for fear of developing a Prozac tolerance) but have usually ended up back on Prozac. Earlier this year my pdoc changed me to Cymbalta and I must say I have never felt better in my entire life! Imagine my despair when after a few months it suddenly stopped working. During my time of success on Cymbalta I can honestly say that I finally knew how being alive and undepressed actually felt. I was happy to wake up, happy to go to sleep, happy to BE. Acknowledging cymbalta's failure, my pdoc then tried myriad other drug and drug combos, to no avail. Six weeks ago it was decided to get me back on Prozac at 40 mg. Here I must note that during my Great Depression of 1999/2010 I was on 80 mgs. I'm rambling because I'm so confused. This time Prozac is not helping at all. My question is has Prozac simply become another Cymbalta for me or should I up the dosage. I realise my pdoc is the one to be answering this question but am wondering if anyone here has experienced similar success then failure on Cymbalta in general and Prozac in particular? I have tremendous responsibilities and so much that needs to be done, but I can't get out of bed for days on end. The only peace I find is in sleep. Please, any insights and feedback will be most welcome.