I can understand seeking enlightenment but in most cases I don't think people reach it through substances. I have self medicated in the past but didn't do it as a conscious decision, just a result of my sickness. I've watched some documentaries about certain substances in the amazon which cure people of physical and mental disorders with one use. Could be real or could be placebo effect, I don't know. It's some form of hallucinogenic. DMT? It's what's released from the brain when we die and is believed to be responsible for people's lives passing through their mind at the time of death. I encourage you to be safe. I do believe many people take drugs recreationally without problems. Seeking Nirvana or chasing a dragon sounds questionable though. I don't think drugs can really do this but I'm not too experienced with having good experiences with anything in general. I've known many people who have had what they claim are mind opening, transformational experiences. I cannot discredit their account of things. Just be careful is all I recommend. The world is hard enough with all our facilities present. Be well.