I have been taking all medications as prescribed, including seroquel and remeron which are my go tos for depression. But yesterday it hit, and hard. I cant get out of bed, cant focus, nightmares, etc. I feel as though my world is falling apart. I dont know quite what to do, but hopefully the remeron and seroquel give me relief soon. Today is supposed to be such a happy day. (Im getting a kitten.) But its not. Its like it comes in waves, mild depression one hour, moderate depression the next hour, and then wham, severe depression. This too shall pass