YES!!!! I'm a Bipolar-I and I had to be treted for anger quickly due to the fact I also a Rapid cycler. My anger was both in the depressive phase and Mania. I was ready to rip myself apart but my Meds DR found a med that brought it to a manageable level within days, and I have not had a real problem with it anymore. Don't get me wrong you still have to work at the jerks not getting to you but my medication helps me with this.Hope this helps!