AspiringAuthor, I didn't realize all the drugs I'm on could be causing my mania. I tend to have depressive episodes more than mania, which is why she has me on this combo. I use Trazodone to help me sleep. I know that both Trazodone and Wellbutrin are antidepressants, but I've been on them so long, I didn't dream they might be causing the problem. I've been on Lamictal since I was diagnosed in 2004. It seems to help with depression, but does nothing for mania. I've heard that higher doses of Lamictal (I'm on 450 mg every day) can actually trigger a manic episode? I'm going to be asking my doctor a lot of questions when I go on Tuesday. I may be manic, but I never want to suffer through those horrible episodes of depression which are so debilitating. Sometimes I think I'm never going to find the right combo for me (I have been on so many, and still have breakthrough episodes). Am I doomed to live like this the rest of my life? I feel so hopeless sometimes.