Well, I had to be upped to 600 mg Seroquel XR to curb a recent moderate mania. Now I'm just great. We are all different. If I only took 100 mg Seroquel XR with my Tegretol XR and Lamictal I'd surely be in very bad shape.

My psychiatrist says that Seroquel or Seroquel XR have a pretty low incidence of EPS. That has shown to be the case for me. I am almost off of Geodon, which gave me akathisia, and the akathisia is gone despite being on Seroquel XR. The meds that gave me akathisia were Zyprexa (right away), Abilify (right away), and eventually Geodon after five and a half years. I've been on at least 300 mg of Seroquel XR for five years now.