Yeah, being a CYP2D6 poor metaboliser, a lot of meds (seroquel included) build up in my body much more than most people. This is true for about 10% of people depending on race. It's why 100mg is plenty for me. 2.5mg zyprexa is a solid dose for me, to the point where I got major side effects and a strong therapeutic effect from a dose so low insurance has tried to cut me off more than once, saying it couldn't possibly be doing anything.

CYP2D6 makes a huge difference in med response.

Anyway, my default baseline when not cycling is moderate to severe depression. Here are the atypicals I've tried.

zyprexa: great for stability. aside from the first time on it, does nothing for depression
abilify: immediate agitation, very bad reaction.
geodon: on it for a month, felt surly and mean.
seroquel: among the best substances I've tried for depression, but I am very unstable.

SIGH.