Yes, meds are different for everybody... which can be frustrating when bringing up a certain med for a certain symptom & like wanting clear-cut answers. I have never been able to entirely figure out before how I will react to an RX or if it will help or worsen me. After 20 + years of varying diagnoses psych docs etc. I (and I am sure many can relate) feel like a lab rat. Yes, I have participated in actual medical studies, but under the care of a psych still feel like a lab rat. With that being said here is my experience with Seroquel and my opinion...
AGITATION- YES!
IRRITABILITY- YES!
Sedation & knocking me out to sleep yes. Even on the smallest or a low dose, I take them (or rather don't) PRN. I wake up feeling crappy as all hell. yes I may have slept which I needed because the psychosis was bad, but nor my body nor mind slept. I was more tired (not including the lingering fogginess) but my body, while was asleep, did not rest to regenerate itself. Any my mind went through hell and back. I wake up in the middle of the night sweating insanely, have not nightmares but night terrors, like trying to wake myself up but can't and if i do have to make myself stay up long enough not to fall back into the night terror. And still then I fall right back into it. I will have my jaw clenched a headache and tears running down my face. Crying in my sleep, for no particular reason just crying and crying. Its not the worst side effect I have suffered from a psych med but it is in my top 3. The next day I am "switching" like mood swings way too rapidly, like 10 minutes tired n just kinda blah, to not wanting to end it all but just like a very concerning level of depression, & irritability not just small cries like oh poor me, but like Emmy award-winning torture cry.
Most medications I would say try to ride out because it takes a while to get in your system and work or not work with your other meds, but it is a very old anti-psychotic like thorazine, think one flew over the coo coos nest. Its kind of a PRN but not exactly. If you have the bad reaction, with these old anti-psychotics as far as my experience and pharmaceutical knowledge the side effects will not even out, maybe lessen but its your mind and body that has to adjust to it it will not adjust to your body and mind.
Hope this helps but doesn't frighten you, if it does I am sorry but I don't want anyone to experience what I had to.