For me (everyone is different) having been on seroquel and various other older medications since about age 19 (33 now) it definitely gave me Akathesia- Tardive- and muscle spasms uncontrollable ticks. They would always prescribe cogentin or propranolol to combat the side effects... yes more pills.... I have been off medications that cause those side effects for about 4-5 years now. I still have permanent ticks akathesia and tardive(not very often). They are not always present but will flare up... while sleeping sometimes the ticks... also when my anxiety is high or just for no reason my hands tremor very badly. I used to be a decent artist, but now even my handwriting or ability to take a non blurry pic on a cell phone (even with image stabilizer) is a rarity.