I consider Latuda to be my main drug for mood regulation, but I still take Wellbutrin at 450mg for depression. The worst side effect I had was akathisia (which the previous poster may have meant for "crawling out of your skin". It's pretty terrible. On the plus side the beta blocker propranolol eliminated it completely. Well worth the extra drug for me (and it's cheap).

Latuda has never made me sleepy; I take it at dinner. Oh, another slightly bothersome thing; you have to take it with 350 calories.