There is some thought that people with depression are more prone to like opioids because, at least while you're on them (and before it spirals out of control), they really are pretty effective at treating some aspects of it. I know big pharma is poking around these ideas, and kratom - a nontraditional opioid like nothing else we've discovered - can have significant antidepressant activity. It was the best antidepressant I ever took, but it was not without problems, believe me.

There is hope that we will get better meds out of this research, but for right now, it's a bad plan.