Sundance - Quite often docs will slowly increase Effexor XR™ (venlafaxine) doses to get to an effective dose. This is to allow your body to adjust to the medication and avoid side effects. Most people take between 150 mg and 300 mg daily of effexor as an effective maintenance dose.

You really should not experience any uncomfortable side effects increasing your daily dose from 75 mg to 112.5 mg. Even if you do, the side effects should not cause any real discomfort.

Good luck - Cam