When I went off seroquel the only side effect I had was extreme nausea. I initially did it cold turkey (from 300mg), but that didn't work out so well so I tapered. It was hard to get off of. Luckily I wasn't taking it for sleep, so that wasn't affected.
I'd go slower than jumping down 100mg. Maybe going down by 50mg would be better, but you'd have to ask your doctor.
Good luck!
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