The conversation with your friend might not be as bad as you think. When my best friend saw my antidepressants, here's what he said:

"You don't look depressed."
"I'm really not anymore, that's why I take the pills."
"Ok, well then what are you depressed about?"
"Absolutely nothing. That's the problem. If I was depressed about something, I could just change it. I was just....depressed."
He shrugged and that was pretty much the end of it.

Actually, quite a few of my friends struggle with depression. Birds of a feather, flock together, right? Anyway, most people don't make a big deal of it. Some ignore it, some find it intriguing, and some just don't care.

They way I figure, those who would make a big deal of it are probably unhealthy influences on my life anyway. I suggest telling someone you're really close with. Just bring it up casually. If they start asking questions, just be honest. If they change the subject, leave it at that.