When someone looks down on you, their judgement and criticism have a lot more to say about them than it does you. Whatever they have going on in their lives have them feeling like they need to be better than someone, so that says they are feeling down on themselves, or that's my take anyway. As far as how to deal with it, create distance whenever possible, nobody needs negativity in their lives.
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Friendship is born at that moment when one person says to another: "What! You, too? Thought I was the only one." C.S. Lewis
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