I can't tell you what the best course of action is for you, but I have been taking Cymbalta for 12 years and my liver values are fine. I do have a small lesion that is likely indicative of nonalcoholic fatty liver. However, this most likely related to a course of accutane I had 5 years ago and/or being on an excessive dose of seroquel for years - either of which could have damaged my insulin resistance, which is related to fatty liver.

Just get your doc to monitor the situation. The first 1-6 months is when this side effect typically appears. Also, it's worth noting that elevated liver enzymes does not usually mean you have irrevocably injured your liver. I'm not sure where the 10% statistic came from, but the NIH reports that about 1% report elevated liver enzymes - but MOST of these were self-limiting and did not require discontinuation or adjustments in dosage.
https://livertox.nih.gov/Duloxetine.htm"]