I had been on 150mg of Zoloft for 15 years and tried to taper off slowly with the approval of my pdoc. Unfortunately, my depression and anxiety returned, and when I went back on the Zoloft, it wasn't working as well as it had in the past. My pdoc added 2mg of Abilify, and it has helped. As an aside, my pdoc never told me, when I was considering tapering off of Zoloft, that there was a risk that it wouldn't work as well in the future. Anyone who is considering discontinuing an SSRI should be aware of this risk. In fact, anyone considering starting an SSRI should be aware of this risk as well. I believe that all patients should be given some kind of informed consent form when they are put on an SSRI.