I started taking seroquel at night to help me sleep, the racing thought just would not go away (anxiety & bipolar 1) started out with 25mg went up to 50mg and that worked pretty well for a while the I had a severe acute manic episode and dr jumped me to 800 with in a matter of days. I really helped but I was extremely tired. I have been brought down to 600mg/day and I am still ok BUT I have gained 35 pounds or so in the last few months so we are slowly weaning me back off and raising my other meds. I really did like the seroquel except the weight gain. They also have the seroquel xr that lasts all day and that one wasn't with the being tired part. Good luck.-Jen