Ok, so I went to the p-doc and we talked and talked and finally he came down to either increasing my wellbutrin to 450 mg, the highest he would go...or wean off wellbutrin and start cymbalta. I chose the latter so now I have 12 days to wean off wellbutrim before starting this. So anyone have any experience with it? He told me it has dual capabilities in that the one part is ssri and the other norepinephrine uptake inhibitor(something like it). And it has been used to treat PN due to diabetes. and of course the depression, which i was rediagnosed as a major relapsing depression. So now after I am on cymbalta for a week i call him with update. In the meantime, he has me seeing a therapist for psychotherapy since meds dont work to cover the depression as a whole...so any one with any history or knowledge that can tell me what i am in forr...i would be indebted. melanie